In vivo NIR-II/swir Fluorescence Imaging

Fluorescence imaging of small animals using existing commercial instruments detect in the ~800-900 nm range, suffering from shallow imaging depth and high background due to light scattering and tissue autofluorescence. NIR-II/SWIR imaging is a revolutionary development detecting in the 1000-1700 nm range to greatly suppress these effects, affording single cell resolution at ~ 3 mm depth and useful resolving power at up to ~ 1 cm depth. Combined with NIR-II probes (molecules, quantum dots and rare-earth nanoparticles) from Nirmidas Biotech, DeepVision™ can be used for vasculature, tumor, brain, lymphatic/lymph node imaging and molecular imaging, empowering research to interrogate cardiovascular, cancer, brain and immune diseases.

Key Features:

• A high performance and cost effective NIR-II/SWIR fluorescence/luminescence system with multiple, customizable lasers
• The only small imaging system detecting in both NIR-I and NIR-II windows: wavelength of imaging spans 400 nm – 1700 nm with high detection efficiency in NIR-II 1000 – 1700 nm range
• For in vivo small animal imaging, ex vivo and in vitro tissue, organism and cellular imaging
• Low and high magnifications adjustable for whole body and microscopic imaging by switchable lens sets
• Capable of single cell and single micro-vasculature imaging resolution in vivo
• Up to 120 frames per second video rate imaging
• Lifetime imaging capability

Inside the DeepVision™:

CCD Camera

• The DeepVision™ CCD camera is ~10 mm x 8 mm with 640 x 512 pixels for high imaging resolution
• 400 – 1700 nm with high detection efficiency
• CCD TE and water cooling to ensure low dark current and low noise

Imaging Chamber

• Light-tight imaging chamber
• 808 nm and 980 nm lasers (customizable)
• Ex/Em filter wheels – 4 filters each
• Heating pad for mouse
• Adjustable imaging field, for whole body or microscopic imaging of mice
• X-Y-Z mouse stage with automated control