Tissuegnostics Info Letter – March 2021

Tissuegnostics Precision that inspires

Colon Cancer Biomarker

Tissue cytometry as tool for prognostic biomarker detection in cancer

A study conducted by a group from the University of Western Australia, published in the journal Cancer Science, explores spatial relationships and the prognostic impact of PD-L1+ dendritic cells and CD8+ T cells on survival of colon cancer patients. The contextual image analysis solution StrataQuest was used for the biomarker assessment.

» get the pdf article

Graft Versus Host Disease

Webinar: In-situ Immunophenotyping in graft-versus host disease

Dr. Johanna Strobl, PhD, from the Medical University of Vienna, Austria, talks about her recently published study addressing host-derived skin-resident memory T cells as potential players in human graft versus host disease. The acquisitions/identification of skin-resident memory T cells in-situ was performed with tissue cytometry solutions.

» watch the webinar

Disseminated Cancer Cells

Assessment of inducers of disseminated cancer cell progression

The group of Prof. Klein (University of Regensburg, Germany) published a paper in Nature Communications investigating initial steps of metastasis formation in breast cancer by performing a comprehensive analysis of disseminated cancer cells and microenvironmental signals in xenografts. TissueFAXS i PLUS and HistoQuest were used to determine expression of various markers.

» get the pdf article

Image Cytometry Solutions

Enhance your research with AI-assisted tissue cytometry

Use TissueGnostics automated analysis solutions to choose from a multitude of analysis options: high-content (immuno)phenotyping by multiplexing/spectral unmixing, spatial context analysis, unlimited tissue classification by machine learning, molecular single-cell profiling using RNA ISH, imaging mass cytometry, pathogen quantification etc.

» watch a short video on tissue cytometry

Chronic Rhinosinusitis

Comprehensive cellular characterization of chronic rhinosinusitis

The group of Giotakis et al (Medical University of Innsbruck, Austria) performed an in-depth analysis of the cellular composition within human chronic rhinosinusitis. Various cell populations, including epithelial-, connective tissue-, and immune cells were characterized in-situ using TissueFAXS and the contextual image analysis solution StrataQuest.

» get the pdf article

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